组会讲课人员:周艳虹
Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation
持续的氧合通过促进上皮化、血管生成以及减少炎症加速糖尿病创面愈合
主讲人:周艳虹
Science Advances,|27 Aug 2021| Vol 7,Issue 35| https://DOI: 10.1126/sciadv.abj0153.
Abstract:
Nonhealing diabetic wounds are common complications for diabetic patients. Because chronic hypoxia prominently delays wound healing, sustained oxygenation to alleviate hypoxia is hypothesized to promote diabetic wound healing. However, sustained oxygenation cannot be achieved by current clinical approaches, including hyperbaric oxygen therapy. Here, we present a sustained oxygenation system consisting of oxygen-release microspheres and a reactive oxygen species (ROS)–scavenging hydrogel. The hydrogel captures the naturally elevated ROS in diabetic wounds, which may be further elevated by the oxygen released from the administered microspheres. The sustained release of oxygen augmented the survival and migration of keratinocytes and dermal fibroblasts, promoted angiogenic growth factor expression and angiogenesis in diabetic wounds, and decreased the proinflammatory cytokine expression. These effects significantly increased the wound closure rate. Our findings demonstrate that sustained oxygenation alone, without using drugs, can heal diabetic wounds.
摘要:
糖尿病创面不愈合是糖尿病患者常见的并发症。由于慢性缺氧显著延迟创面愈合,持续氧合缓解缺氧被假设促进糖尿病创面愈合。然而,目前的临床方法并不能实现持续的氧合,包括高压氧治疗。在这里,我们提出了一个由氧释放微球和活性氧(ROS)清除水凝胶组成的持续氧合系统。水凝胶捕获糖尿病伤口中自然升高的ROS,给药微球释放的氧可能进一步升高。氧气的持续释放增强了角质形成细胞和真皮成纤维细胞的存活和迁移,促进了糖尿病伤口中血管生成生长因子的表达和血管生成,并降低了促炎细胞因子的表达。这些作用显著增加了伤口闭合率。我们的研究结果表明,在不使用药物的情况下单独的持续氧合,可以治愈糖尿病的伤口。