组会讲课人员:何梦洁
Conquering the Hypoxia Limitation for Photodynamic Therapy
克服光动力疗法的缺氧限制
主讲人:何梦洁
Advanced Materials (IF 32.086) Pub Date: 2021-0927, DOI:10.1002/adma.202103978
Abstract:
Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, due to the hypoxic nature characteristic of many solid tumors, PDT is frequently limited in therapeutic effect. Moreover, the consumption of O2 during PDT may further aggravate the tumor hypoxic condition, which promotes tumor proliferation, metastasis, and invasion resulting in poor prognosis of treatment. Therefore, numerous efforts have been made to increase the O2 content in tumor with the goal of enhancing PDT efficacy. Herein, these strategies developed in past decade are comprehensively reviewed to alleviate tumor hypoxia, including 1) delivering exogenous O2 to tumor directly, 2) generating O2 in situ, 3) reducing tumor cellular O2 consumption by inhibiting respiration, 4) regulating the TME, (e.g., normalizing tumor vasculature or disrupting tumor extracellular matrix), and 5) inhibiting the hypoxia-inducible factor 1 (HIF-1) signaling pathway to relieve tumor hypoxia. Additionally, the O2-independent Type-I PDT is also discussed as an alternative strategy. By reviewing recent progress, it is hoped that this review will provide innovative perspectives in new nanomaterials designed to combat hypoxia and avoid the associated limitation of PDT.
摘要:
光动力疗法(PDT)因其时空选择性高、侵入性小、全身毒性小等特点,近年来引起了人们的极大研究兴趣。然而,由于许多实体瘤的缺氧性质特征,PDT的治疗效果往往受到限制。而且,消耗的O2在PDT期间可能进一步加重肿瘤缺氧状况,从而促进肿瘤增殖、转移和侵袭,导致治疗预后不良。因此,已经做出了许多努力来增加O2肿瘤中的内容,目的是增强PDT疗效。本文全面回顾了过去十年中开发的这些策略以缓解肿瘤缺氧,包括1)提供外源性O2直接递送到肿瘤部位,2)原位产生O2,3)通过抑制肿瘤细胞呼吸减少O2消耗,4)调节TME(例如,使肿瘤脉管系统正常化或破坏肿瘤细胞外基质)和5)抑制缺氧诱导因子1(HIF-1)信号通路以缓解肿瘤缺氧。此外,O2-独立的I型PDT也被讨论为一种替代策略。通过回顾最近的进展,希望本综述将为旨在对抗缺氧和避免PDT相关限制的新纳米材料提供创新视角。