组会讲课人员:陈萌森
Chemiluminescent 1,2-Dioxetane Iridium Complexes for Near-Infrared Oxygen Sensing
用于近红外氧传感的化学发光 1,2-二氧杂环丁烷铱配合物
主讲人:陈萌森
Angewandte Chemie International Edition ( IF 16.823 ) Pub Date : 2022-01-17 , DOI: 10.1002/anie.202115704
Abstract:
hemiluminescent iridium-based sensors which demonstrate oxygen dependent responses have been developed. The molecular probes, named IrCL-1, IrCL-2 and IrCL-3 consist of oxygen-sensitive iridium complexes attached to a spiroadamantane 1,2 dioxetane and operate via energy transfer from the chemiexcited benzoate to the corresponding iridium(III) complex. Complexing the iridium-(III) center with π-extended ligands results in emission in the biologically relevant, near-infrared (NIR) region. All probes demonstrate varying oxygen tolerance, with IrCL-1 being the most oxygen sensitive. These probes have been further utilized for in vitro ratiometric imaging of oxygen, as well as for intraperitoneal, intramuscular and intratumoral imaging in live mice. To our knowledge, these are the first iridiumbased chemiluminescent probes that have been employed for in vitro ratiometric oxygen sensing, and for in vivo tumor imaging.
摘要:
已开发出基于铱的化学发光传感器,该传感器具有氧依赖性响应。名为 IrCL-1、IrCL-2 和 IrCL-3 的分子探针由与螺金刚烷 1,2 二氧杂环丁烷连接的氧敏感铱配合物组成,并通过从化学激发的苯甲酸盐到相应的铱 (III) 络合物的能量转移进行操作.将铱-(III) 中心与π- 扩展配体络合导致在生物学相关的近红外 (NIR) 区域发射。所有探针都表现出不同的氧气耐受性,其中 IrCL-1 对氧气最敏感。这些探针已进一步用于氧的体外比例成像,以及活小鼠的腹膜内、肌肉内和肿瘤内成像。据我们所知,这些是第一个基于铱的化学发光探针,已用于体外比率氧传感和体内肿瘤成像。